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Key gap drivers typically stem from whether ready-to-use components are bundled, how ASP erosion is modeled, and the aggressiveness of pipeline growth assumptions

Activation of 1 receptors increases intracellular cAMP, which: Activates protein kinase A (PKA) Phosphorylates L-type calcium channels Increases calcium influx into the cell Calcium entry triggers calcium-induced calcium release (CICR) from the sarcoplasmic reticulum via ryanodine receptors, increasing intracellular calcium available to bind troponin C, thereby enhancing myocardial contractility (positive inotropy)

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